Embark on an unforgettable journey from the bustling metropolis of Cincinnati, Ohio, to the picturesque mountain town of Gatlinburg, Tennessee. This 300-mile road trip meanders through the scenic landscapes of Kentucky and Tennessee, promising breathtaking views, cultural immersion, and endless opportunities for adventure. Prepare to be captivated by the allure of the Appalachian Mountains and discover hidden gems along the way.

Planning Your Road Trip
Estimated Driving Time: Approximately 6-7 hours
Suggested Route:
- Cincinnati, OH → Lexington, KY (100 miles)
- Lexington, KY → Knoxville, TN (150 miles)
- Knoxville, TN → Gatlinburg, TN (50 miles)
When to Go:
The best time to experience this road trip is during the fall foliage season (late September to early November) when the Appalachian Mountains burst into a vibrant tapestry of colors. However, springtime offers its own allure with blooming dogwoods and wildflowers.
Distance and Driving Conditions:
The total distance between Cincinnati and Gatlinburg is approximately 300 miles. The roads are generally well-maintained, but some sections may experience traffic congestion during peak travel periods.
Points of Interest Along the Way
Lexington, Kentucky
- Keeneland Race Course: Witness the thrill of thoroughbred horse racing at one of the most renowned tracks in the world.
- Lexington Cemetery: Explore the historic resting place of famous figures such as Henry Clay and Mary Todd Lincoln.
- Ashland, The Henry Clay Estate: Discover the opulent mansion and gardens that were home to the “Great Compromiser” of American politics.
Knoxville, Tennessee
- Sunsphere: Ascend to the iconic observation tower for panoramic views of the city and surrounding mountains.
- Ijams Nature Center: Immerse yourself in nature’s embrace with hiking trails, a wildlife sanctuary, and a scenic riverfront park.
- East Tennessee Historical Society Museum: Delve into the rich history of the region through interactive exhibits and artifacts.
Great Smoky Mountains National Park
- Newfound Gap Road: Drive through the heart of the national park, marveling at towering peaks, cascading waterfalls, and abundant wildlife.
- Cades Cove Loop Road: Explore a historic valley dotted with preserved cabins, churches, and breathtaking mountain views.
- Sugarlands Visitor Center: Gather information about park activities, ranger programs, and hiking trails.
Accommodation and Dining
Lexington, Kentucky
- 21c Museum Hotel Lexington: A contemporary art-filled hotel with stylish rooms and a renowned restaurant.
- The Campbell House: A historic bed and breakfast with elegant accommodations and a cozy atmosphere.
Knoxville, Tennessee
- The Tennessean: A modern downtown hotel offering comfortable rooms and convenient dining options.
- The Oliver Hotel: A boutique hotel in a restored historic building with upscale amenities and a charming restaurant.
Gatlinburg, Tennessee
- The Park Vista – A DoubleTree by Hilton Hotel: A mountainside hotel with stunning views and a variety of amenities.
- Anakeesta: A mountaintop adventure park offering zip lines, suspension bridges, and scenic observation decks.
Culinary Delights:
- Lexington, Kentucky: Sample traditional Southern fare such as fried chicken, barbecue ribs, and bourbon.
- Knoxville, Tennessee: Indulge in farm-to-table cuisine, featuring Appalachian specialties like pimento cheese and cornbread.
- Gatlinburg, Tennessee: Experience the Smoky Mountain flavors with hearty pancakes, homemade jams, and locally brewed beer.
Essential Tips
- Plan your stops to accommodate rest, meals, and sightseeing.
- Book your accommodation in advance, especially during peak season.
- Pack for all types of weather conditions, as the Appalachian weather can be unpredictable.
- Bring plenty of snacks and water to stay hydrated during your journey.
- Allow ample time for scenic drives and overlook stops.
- Respect wildlife and stay on designated trails.
- Check road conditions before you depart and be aware of any potential delays or closures.
Benefits of the Cincinnati to Gatlinburg TN Road Trip
- Panoramic Scenery: Witness the breathtaking beauty of the Appalachian Mountains, from rolling hills to majestic peaks.
- Historical Immersion: Discover the rich history of Kentucky and Tennessee, from horse racing to the Civil War.
- Outdoor Adventure: Explore the Great Smoky Mountains National Park, offering endless opportunities for hiking, fishing, and wildlife viewing.
- Cultural Experiences: Engage with the vibrant Appalachian culture through music, crafts, and local traditions.
- Gastronomic Delights: Savor the unique culinary offerings of each city, from Southern comfort food to mountain treats.
FAQs
Q: How far is Gatlinburg, TN from Cincinnati, OH?
A: Approximately 300 miles.
Q: What is the most scenic route to take?
A: Newfound Gap Road and Cades Cove Loop Road in the Great Smoky Mountains National Park offer stunning views.
Q: Can I visit the Great Smoky Mountains National Park in one day?
A: While possible, it is recommended to allocate at least 2-3 days for a more immersive experience.
Q: Are there any tolls along the route?
A: No, there are no toll roads on the suggested route.
Q: Can I bring my pet?
A: Some pet-friendly accommodations are available, but check with individual hotels for specific policies.
Q: What is the best way to find affordable accommodation?
A: Consider staying in smaller towns along the route or booking your lodging in advance during the off-season.
Q: What are the most popular things to do in Gatlinburg, TN?
A: Visiting the Great Smoky Mountains National Park, exploring Ober Gatlinburg amusement park, and experiencing the Gatlinburg Space Needle are top attractions.
Q: Is this road trip suitable for all ages?
A: Yes, it is generally family-friendly, but consider each person’s physical abilities when planning activities.