Introduction

Interstate 81 (I-81) is a major north-south interstate highway in the eastern United States. It stretches for 325 miles from the Canadian border in New York to the Tennessee state line, passing through Pennsylvania, Maryland, Virginia, and Tennessee. I-81 provides a vital connection between major cities such as Syracuse, Binghamton, Scranton, Harrisburg, Roanoke, and Bristol.
If you’re planning to travel southbound on I-81, here are detailed directions to help you navigate your journey:
Heading South from New York
New York State
- From the Canadian Border: Begin your journey on I-81 southbound at the Canadian border crossing in Rouses Point, New York.
- Through Syracuse: Continue south on I-81 through Syracuse, New York’s fifth-largest city, known for its famed Carrier Dome stadium.
- To Binghamton: Proceed southbound on I-81 to Binghamton, a major industrial and cultural center in southern New York.
Pennsylvania
- Entering Pennsylvania: Cross the state line into Pennsylvania at Great Bend, Pennsylvania, where you will continue on I-81 southbound.
- Through Scranton: Pass through Scranton, Pennsylvania’s sixth-largest city, famous for its historical architecture and the Electric City Trolley Museum.
- To Harrisburg: Continue south on I-81 to Harrisburg, Pennsylvania’s state capital and home to the Pennsylvania State Capitol Complex.
Heading South from Pennsylvania
Maryland
- Entering Maryland: Cross the state line into Maryland at Hagerstown, Maryland, where you will remain on I-81 southbound.
- Through Frederick: Pass through Frederick, Maryland’s second-largest city, known for its quaint historic downtown and the National Museum of Civil War Medicine.
- To Baltimore: Continue south on I-81 towards Baltimore, Maryland’s largest city and a major cultural and economic hub.
Virginia
- Entering Virginia: Cross the state line into Virginia at Martinsburg, West Virginia, where you will continue on I-81 southbound.
- Through Winchester: Pass through Winchester, Virginia’s northernmost city, known for its historic downtown and the Shenandoah Valley Civil War Museum.
- To Roanoke: Continue south on I-81 to Roanoke, Virginia’s largest inland city and a major transportation hub.
Heading South from Virginia
Tennessee
- Entering Tennessee: Cross the state line into Tennessee at Bristol, Tennessee, where you will remain on I-81 southbound.
- Through Kingsport: Pass through Kingsport, Tennessee, a major industrial and cultural center in northeastern Tennessee.
- To Knoxville: Continue south on I-81 to Knoxville, Tennessee’s third-largest city and a major educational and economic hub.
Exit Points and Destinations
Along I-81 southbound, there are numerous exit points and destinations to choose from. Here are some key exits and their destinations:
Exit Number | Destination |
---|---|
9 | Rouses Point, NY (Canadian border) |
39 | Syracuse, NY |
65 | Binghamton, NY |
101 | Scranton, PA |
136 | Harrisburg, PA |
172 | Hagerstown, MD |
189 | Frederick, MD |
219 | Baltimore, MD |
229 | Martinsburg, WV (VA border) |
254 | Winchester, VA |
271 | Roanoke, VA |
286 | Bristol, TN (VA border) |
295 | Kingsport, TN |
308 | Knoxville, TN |
Tips for Navigating I-81 Southbound
- Plan your route ahead: Determine your starting and ending points and identify potential rest stops or gas stations along the way.
- Allow ample time: I-81 can be a busy highway, especially during peak hours. Allow extra time for potential traffic delays.
- Stay alert: Pay attention to road signs and be aware of changing traffic conditions.
- Take breaks: If you’re driving for an extended period, take regular breaks to rest and avoid fatigue.
- Use technology: Utilize GPS navigation systems or smartphone maps to help you stay on track and find your destination.
FAQs
- How long does it take to drive the entire length of I-81 southbound? The estimated driving time for the entire length of I-81 southbound is approximately 6-7 hours, depending on traffic conditions.
- Are there any major cities along I-81 southbound? Yes, major cities along I-81 southbound include Syracuse, NY, Binghamton, NY, Scranton, PA, Harrisburg, PA, Roanoke, VA, and Knoxville, TN.
- What are the speed limits on I-81 southbound? Speed limits on I-81 southbound vary depending on the state and specific section of the highway. Refer to posted signage for the current speed limit.
- Are there tolls on I-81 southbound? No, there are no tolls on I-81 southbound.
- What are the exits for major destinations along I-81 southbound? See the table provided earlier for exit numbers and destinations along I-81 southbound.
- Can I access the Blue Ridge Parkway from I-81 southbound? Yes, you can access the Blue Ridge Parkway from I-81 southbound at Exit 172 in Hagerstown, MD.